University of Colorado Denver/Anschutz Medical Campus · Biochemistry

Muscle Disease Research Laboratory

Sujatha Jagannathan · Denver, Colorado

Research Focus

Dr. Sujatha Jagannathan's lab at the University of Colorado Denver focuses on understanding a muscle disease called facioscapulohumeral muscular dystrophy (FSHD). The lab's research investigates how a protein called DUX4 disrupts RNA processing in muscle cells, leading to toxicity and muscle degeneration. By uncovering the molecular mechanisms at play, the lab aims to identify potential new treatments for FSHD and other similar neuromuscular conditions.

DUX4muscle diseaseRNA processingRNA metabolismfacioscapulohumeral muscular dystrophyneuromuscular diseasesgene regulationproteomicsubiquitin-proteasome system

Research Aims

AIM 01Investigate how DUX4 induces aberrant RNA splicing in muscle cells.

AIM 02Identify mechanisms that lead to loss of RNA quality control upon DUX4 expression.

AIM 03Understand the role of DUX4 in rewiring the post-transcriptional gene regulatory network.

AIM 04Determine the pathways involved in DUX4-driven toxicity in muscle cells.

Skills the Lab Values

RNA sequencingCRISPR gene editingproteomicscell culture techniquesbiochemical assaysmass spectrometrysplicing analysisimmunoprecipitationgenome engineering

Output against the department

Publications50bottom 7% of dept.372nd of 402

this lab

most publishedleast published

Citations1.2kbottom 4% of dept.384th of 402

this lab

most citedleast cited

Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.