University of Kentucky · BiologyWang Neuroinflammation Lab
Wang-Xia Wang · Lexington, Kentucky
Research Focus
Dr. Wang-Xia Wang’s lab at the University of Kentucky focuses on understanding how microRNAs influence neuroinflammation and the role they play in Alzheimer's disease. The lab is particularly interested in a specific microRNA, miR-223, which affects the ApoE pathway, a critical component linked to neuroinflammation and sex-related differences in disease response. Through various experimental techniques, the lab aims to develop new therapeutic strategies that could improve treatment outcomes for Alzheimer's disease, especially in female patients who may be disproportionately affected by these conditions.
microRNAneuroinflammationAlzheimer's diseaseApoE dysregulationliposome deliverysex differencesCEBPtherapeutic strategy
Research Aims
5AIM 01Investigate the role of miR-223 in regulating the CEBP-ApoE pathway.
AIM 02Assess the impact of miR-223 delivery via liposomes on neuroinflammation.
AIM 03Evaluate the miR-223 pathway in a brain injury mouse model.
AIM 04Analyze the miR-223 effects in human cells in relation to Alzheimer's pathology.
AIM 05Explore the gender-specific mechanisms underlying Alzheimer's disease and neuroinflammation.
Skills the Lab Values
PCRliposome formulationmouse modelscell cultureRNA isolationWestern blotflow cytometryin vivo experimentshuman cell assaysbiostatistics
Output against the department
Publications95bottom 33% of dept.691st of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.283rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.