University of Kentucky · PhysiologyChronoCardio Lab
Ming C Gong · Lexington, Kentucky
Research Focus
Dr. Ming C Gong's lab at the University of Kentucky focuses on understanding how specific medications can help regulate blood pressure in people with type 2 diabetes. They are particularly interested in a new class of diabetes drugs that have shown promise for not only managing blood sugar but also improving blood pressure patterns. By studying the effects of these drugs at different times of the day, the lab aims to find better treatment strategies for diabetic patients who experience high blood pressure.
Type 2 diabetesblood pressureGLP-1 receptorchronotherapycardiovascular healthcircadian rhythmsmetabolismsympathetic nervous systempre-clinical studies
Research Aims
5AIM 01Investigate GLP-1RA as a novel chronomedicine to protect blood pressure circadian rhythm.
AIM 02Define the mechanism by which GLP-1RA protects blood pressure circadian rhythm in diabetes.
AIM 03Assess the effects of GLP-1RA on metabolism and food intake during different times of the day.
AIM 04Explore the role of sympathetic nervous system in regulating blood pressure with GLP-1RA.
AIM 05Determine the impact of GLP-1 receptor signaling on clock genes and metabolic rhythms.
Skills the Lab Values
in vivo mouse modelscircadian rhythm analysisdrug administration techniquesmolecular biology techniquesgene knockout techniquesmetabolic measurementsdata analysisfood intake monitoringphysiological assays
Output against the department
Publications127bottom 40% of dept.169th of 286
this lab
most publishedleast published
Citations4.0kbottom 34% of dept.190th of 286
this lab
most citedleast cited
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