University of Michigan-Ann Arbor · PharmacologyTessier Neuroprotection Lab
Peter M Tessier · Ann Arbor, Michigan
Research Focus
Dr. Peter Tessier's lab focuses on innovative strategies to deliver therapeutic antibodies across the blood-brain barrier for treating Alzheimer's disease. The lab researches the use of bispecific antibodies to improve the delivery of neuroprotective agents and gene silencing methodologies in microglia, the immune cells of the brain, without invasive procedures. By optimizing these antibody-based delivery systems, they aim to enhance treatment efficacy and develop new therapies for neurodegenerative disorders.
Alzheimer's diseaseneuroprotectionblood-brain barrierbispecific antibodiesgene expression modulationmicrogliatherapeutic antibodiesantisense oligonucleotidesbrain-targeted delivery
Research Aims
3AIM 01Optimize delivery of neuroprotective antibodies across the blood-brain barrier.
AIM 02Assess the efficacy of antibody shuttles in mouse models of Alzheimer's disease.
AIM 03Develop new strategies for modulating microglia gene expression using bispecific antibodies.
Skills the Lab Values
cell cultureantibody engineeringanimal modelsflow cytometryWestern blottingmolecular cloningPCRhistologyin vivo imagingdata analysis
Output against the department
Publications146bottom 41% of dept.271st of 462
this lab
most publishedleast published
Citations7.0kbottom 49% of dept.235th of 462
this lab
most citedleast cited
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