Washington University in St Louis · BiologyWan Lab
Xiaoxiao Wan · Saint Louis, Missouri
Research Focus
Dr. Xiaoxiao Wan's lab at Washington University explores how certain molecules in pancreatic beta cells can trigger autoimmunity, specifically in type 1 diabetes. The lab focuses on understanding neoepitopes—modified pieces of proteins that can provoke harmful immune responses. By studying how these neoepitopes are formed and their role in autoimmune diseases, particularly type 1 diabetes, the lab aims to identify new targets for potential therapies and improve our understanding of disease mechanisms.
autoimmunitytype 1 diabetesneoepitopescrinophagyT cell pathogenicity
Research Aims
5AIM 01Investigate the role of beta-cell crinophagy in generating immunogenic neoepitopes.
AIM 02Characterize the pathogenicity of autoreactive T cells that target neoepitopes in type 1 diabetes.
AIM 03Identify potential translational applications of neoepitopes in human crinophagy.
AIM 04Examine peptide post-translational modifications in crinosomes related to autoimmune diabetes.
AIM 05Explore the pathogenic link between beta-cell stress and autoimmune responses in type 1 diabetes.
Skills the Lab Values
immunopeptidomicsmouse modelscell cultureantigen presentation assaysflow cytometry
Output against the department
Publications122bottom 44% of dept.581st of 1,033
this lab
most publishedleast published
Citations1.5kbottom 9% of dept.938th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.