University of Arizona · PharmacologyStreicher Pain Lab
John Michael Streicher · Tucson, Arizona
Research Focus
Dr. John Michael Streicher's lab at the University of Arizona focuses on developing innovative therapies to better manage chronic pain while minimizing the use of opioids. They investigate a protein called Heat Shock Protein 90 (Hsp90), which plays a key role in how opioids work in the brain and spinal cord. By creating selective inhibitors of Hsp90, the lab aims to enhance the effectiveness of opioids for pain relief while reducing unwanted side effects like tolerance and addiction.
chronic painopioid reductionHsp90 inhibitorsdrug developmentpain management
Research Aims
3AIM 01Develop isoform-selective Hsp90 inhibitors to enhance opioid therapy
AIM 02Optimize existing compounds for better solubility and pharmacokinetics
AIM 03Test the efficacy of new compounds in pain models to assess anti-nociceptive effects
Skills the Lab Values
medicinal chemistrydrug formulationanimal modelsin vivo pharmacokineticsmolecular biology techniques
Output against the department
Publications152bottom 42% of dept.267th of 462
this lab
most publishedleast published
Citations3.1kbottom 23% of dept.356th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.