MCWMedical College of Wisconsin · Microbiology & Immunology
Kristich Lab
Christopher J Kristich · Milwaukee, Wisconsin
Research Focus
Dr. Christopher J. Kristich's lab focuses on understanding how certain bacteria, specifically enterococci, become resistant to antibiotics. The lab investigates the dynamics of proteins that help these bacteria resist treatments, as well as how intracellular signals influence this resistance. Their work aims to uncover new targets for developing innovative antibiotics that can effectively fight these resistant infections, which are a significant issue in hospitals.
antibiotic resistanceenterococcipenicillin-binding proteinsnucleotide signalinghospital-acquired infectionsantimicrobial therapeuticscephalosporin resistancebacterial cell envelopebiochemical mechanisms
Research Aims
5AIM 01Investigate the conformational dynamics of penicillin-binding proteins in enterococci.
AIM 02Understand the regulatory mechanisms of nucleotide signal synthesis in response to cell wall stress.
AIM 03Identify new biochemical targets that contribute to enterococcal cephalosporin resistance.
AIM 04Explore the roles of specific proteins in antibiotic resistance mechanisms.
AIM 05Develop innovative strategies for overcoming enterococcal antimicrobial resistance.
Skills the Lab Values
PCRcell cultureprotein crystallographybiophysical techniquescryoelectron microscopyWestern blotmolecular modelingRNA isolationbacterial transformation
Output against the department
Publications68bottom 20% of dept.388th of 486
this lab
most publishedleast published
Citations3.1kbottom 21% of dept.382nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.