Massachusetts Institute of Technology · ChemistryAmyloid Structures and Dynamics Lab
Robert Guy Griffin · Cambridge, Massachusetts
Research Focus
Dr. Robert Guy Griffin's lab at MIT focuses on understanding the structures of amyloid proteins, which are crucial in diseases like Alzheimer's. The lab uses advanced techniques in nuclear magnetic resonance (NMR) to study how these proteins form and interact, particularly looking at how certain variations can affect their properties and the development of amyloid-related diseases. This research aims to provide atomic-level insights that could lead to new treatments for amyloid-related conditions.
Amyloid ProteinsNMR SpectroscopyAlzheimer's DiseasePeptide StructureCryo-electron MicroscopyMagic Angle SpinningDNP TechniquesAmyloid PolymorphismAntibody InteractionStructure-Function Relationship
Research Aims
4AIM 01Determine the structure of amyloid peptides A1-40 and A1-42 using MAS NMR and cryoEM techniques.
AIM 02Investigate the structure of beta-2-microglobulin and its variants related to dialysis-related amyloidosis.
AIM 03Study amyloid polymorphism by examining the structural characteristics of different amyloid forms.
AIM 04Develop and refine NMR methods for more accurate structural analysis of amyloid proteins.
Skills the Lab Values
Magic Angle Spinning NMRNMR Data AnalysisCryo-electron MicroscopyProtein PurificationMolecular Structure DeterminationSample Preparation for NMRSpectroscopy TechniquesBiophysical CharacterizationExperimental DesignQuantitative Distance Measurements
Output against the department
Publications744top 8% of dept.18th of 216
this lab
most publishedleast published
Citations50ktop 7% of dept.15th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.