University at Buffalo · NeuroscienceATP1A3 Neurological Research Lab
Allison Brashear · Buffalo, New York
Research Focus
Dr. Allison Brashear's lab at the University at Buffalo focuses on studying the genetic mutations of the ATP1A3 gene, which can cause a variety of neurological disorders. By employing a mix of patient phenotyping and laboratory testing, the lab aims to understand the symptoms related to these mutations and find potential treatments. They explore how these mutations affect cellular functions and how existing drugs can be used to alleviate symptoms, ultimately hoping to broaden diagnosis and treatment options for affected individuals.
ATP1A3 geneneurological disordersgenetic mutationsphenotypingdrug testing
Research Aims
3AIM 01Expand ATP1A3 phenotyping using diagnostic tools
AIM 02Assess ATP1A3 mutations as risk factors for diseases
AIM 03Investigate protein misfolding due to ATP1A3 mutations and test drug efficacy
Skills the Lab Values
cell culturepatient phenotypinggenomic sequencingdata analysisprotein misfolding assays
Output against the department
Publications217top 34% of dept.226th of 671
this lab
most publishedleast published
Citations7.5ktop 50% of dept.333rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.