Texas A&M University-College Station · BiochemistryEntropy Dynamics Lab
A. Joshua Wand · College Station, Texas
Research Focus
Professor A. Joshua Wand's lab at Texas A&M Agrilife Research focuses on understanding how proteins work and how their structures affect their functions in health and diseases. The lab studies the impact of entropy, a measure of disorder, on the stability and function of proteins, particularly in the context of diseases like Parkinson's. By exploring these relationships, the lab aims to uncover new pathways for disease intervention and develop strategies to address various health issues related to protein dysfunction.
protein structureentropyallosteric regulationNMR spectroscopymembrane proteinsenzymatic activitythermodynamicsParkinson's diseasebiomedical researchstructural biology
Research Aims
5AIM 01Investigate the role of conformational entropy in protein function and stability.
AIM 02Explore allosteric regulation mechanisms in proteins associated with diseases like Parkinson's.
AIM 03Examine dynamic differences between membrane proteins and soluble proteins.
AIM 04Study the thermodynamics of enzyme catalysis and transition states.
AIM 05Develop new methods to study protein dynamics using NMR-based strategies.
Skills the Lab Values
NMR spectroscopyprotein purificationgel electrophoresismembrane protein assayskinetic analysiscrystallographycell culturedata analysis with Pythonstructural modelingthermodynamic profiling
Output against the department
Publications260top 27% of dept.109th of 402
this lab
most publishedleast published
Citations13ktop 37% of dept.148th of 402
this lab
most citedleast cited
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