University of Pennsylvania · PhysiologyDominguez Lab
Roberto Dominguez · Philadelphia, Pennsylvania
Research Focus
Roberto Dominguez's lab focuses on understanding the actin cytoskeleton, which is crucial for various cellular processes such as movement, shape, and organization. The research investigates how specific proteins help regulate the dynamics of actin filaments, which has implications for cell motility and disease progression, particularly in cancer. The lab also aims to develop innovative tools that can precisely manipulate these proteins in order to enhance research and therapeutic interventions.
actin cytoskeletoncell motilityorganelle movementmetastatic cancerphotoswitchable compoundscytoskeletal proteinsdynamics regulationstructural biologymechanosensation
Research Aims
4AIM 01Understand how NPF-binding sites influence Arp2/3 complex activation.
AIM 02Investigate the mechanisms of filament stability and disassembly in actin networks.
AIM 03Explore the cytoskeletal processes affecting mitochondrial dynamics.
AIM 04Develop photoswitches for targeted actin manipulation.
Skills the Lab Values
cell cultureprotein purificationmicroscopyRNA sequencingbiochemical assaysCRISPRfluorescence microscopyWestern blotmolecular cloningcomputational modeling
Output against the department
Publications285top 19% of dept.53rd of 286
this lab
most publishedleast published
Citations12ktop 27% of dept.77th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.