Duquesne University · ChemistryCascio Structural Lab
Michael Cascio · Pittsburgh, Pennsylvania
Research Focus
Dr. Michael Cascio's lab studies the structure and interactions of glycine receptors, which are important proteins that help nerve cells communicate. By using advanced techniques such as crosslinking mass spectrometry, the lab aims to understand how these receptors change in response to different conditions and molecules, including drugs. The insights gained could be crucial for developing new therapies for neurological disorders.
glycine receptorscrosslinking mass spectrometryprotein structureallosterylipid bilayers
Research Aims
5AIM 01Investigate the structure of the intracellular domain of glycine receptors using CXMS.
AIM 02Examine how different allosteric states affect glycine receptor structure.
AIM 03Characterize lipid-protein interactions in glycine receptors.
AIM 04Assess the influence of crosslinker length on receptor structure.
AIM 05Understand the relationship between glycine receptor structure and function.
Skills the Lab Values
crosslinking mass spectrometryprotein purificationlipid bilayer reconstitutionbiochemical assaysdata interpretation
Output against the department
Publications87bottom 18% of dept.176th of 216
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.178th of 216
this lab
most citedleast cited
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