Oregon Health & Science University · BiologySacha Lab
Jonah B. Sacha · Portland, Oregon
Research Focus
Dr. Jonah B. Sacha's lab focuses on understanding how certain immune responses can lead to the cure of HIV. By studying the effects of allogeneic hematopoietic stem cell transplantation in both cured HIV patients and macaques, the lab aims to uncover specific T cell responses that can effectively eliminate the viral reservoir. Their research has significant public health implications, as it could lead to new therapeutic methods for HIV treatment.
HIVHematopoietic stem cell transplantationAllogeneic T cellsViral reservoirCure research
Research Aims
3AIM 01Define allogeneic T cell responses in HIV cured individuals
AIM 02Characterize allogeneic T cell targets in macaques cured of SIV
AIM 03Evaluate safety and efficacy of allogeneic T cells in humanized mouse models for HIV cure
Skills the Lab Values
Cell cultureFlow cytometryAdoptive T cell transferAnimal modelsImmunological assays
Output against the department
Publications151top 45% of dept.460th of 1,033
this lab
most publishedleast published
Citations6.2kbottom 45% of dept.569th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.