WMCWeill Medical College of Cornell University · Neuroscience
Manfredi Lab
Giovanni Manfredi · New York, New York
Research Focus
Dr. Giovanni Manfredi's lab focuses on understanding how mitochondrial dysfunction contributes to neurological diseases, including conditions like Alzheimer's and Parkinson's. They explore the complex roles mitochondria play in cellular metabolism and how stress responses are activated when mitochondrial function is impaired. This research aims to develop new therapeutic strategies to combat mitochondrial disorders and their effects on the central nervous system.
mitochondriamitochondrial dysfunctionneurological diseasesmetabolic pathwaysstress responseneurodegenerationmitochondrial encephalopathiescell metabolismAlzheimer's diseaseParkinson's disease
Research Aims
5AIM 01Investigate the role of mitochondrial dysfunction in neurological diseases.
AIM 02Identify metabolic rewiring in disease models of mitochondrial encephalopathies.
AIM 03Explore the mitochondrial integrated stress response in the central nervous system.
AIM 04Develop therapeutic strategies targeting metabolic imbalances in affected cells.
AIM 05Enhance understanding of pathogenic mechanisms underlying mitochondrial diseases.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingmetabolic profilingimmunofluorescence microscopytranscriptional analysisCRISPRbioinformaticsin vitro assays
Output against the department
Publications299top 23% of dept.151st of 671
this lab
most publishedleast published
Citations17ktop 24% of dept.163rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.