Stanford University · BiologyThe Calcineurin Connection
Martha S. Cyert · Stanford, California
Research Focus
Dr. Martha S. Cyert's lab at Stanford University focuses on understanding how calcineurin, a crucial protein involved in calcium signaling, works at cellular membranes. The research explores how calcineurin interacts with proteins through a process called S-acylation, which involves the addition of fatty acids to proteins. This work has implications for diseases such as cancer and immune disorders, as well as a better understanding of cellular processes and potential therapeutic targets.
calcineurinS-acylationprotein signalingcancer biologycell membrane
Research Aims
5AIM 01Investigate the regulation of calcineurin at cellular membranes.
AIM 02Identify enzymes involved in S-acylation of calcineurin isoforms.
AIM 03Examine the role of calcimembrin in cancer signaling pathways.
AIM 04Understand how S-acylation influences protein interactions at membranes.
AIM 05Explore new therapeutic strategies targeting calcineurin in disease contexts.
Skills the Lab Values
cell cultureWestern blotimmunoprecipitationgenetic manipulation in yeastbiochemical assaysconfocal microscopyprotein purificationRNA isolationdata analysis with Python
Output against the department
Publications87bottom 28% of dept.735th of 1,033
this lab
most publishedleast published
Citations8.2ktop 46% of dept.478th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.