Pennsylvania State University-Main Campus · PhysiologyThe Viral Structure Lab
Joseph Che-Yen Wang · University Park, Pennsylvania
Research Focus
Dr. Joseph Che-Yen Wang's lab focuses on studying the Hepatitis B virus (HBV), which is a major global health issue affecting millions. The lab uses advanced imaging techniques, particularly cryo-electron microscopy, to explore the detailed structures of HBV capsids and virions as they develop in human cells. This research aims to uncover the mechanisms of viral replication and potential targets for new antiviral treatments.
Hepatitis B viruscapsid structurecryo-electron microscopyviral replicationantiviral therapeutics
Research Aims
4AIM 01Characterize the high-resolution structures of HBV capsids from human cells.
AIM 02Investigate the structural changes of capsids during genome maturation.
AIM 03Determine how HBV capsids interact with viral envelope proteins.
AIM 04Integrate structural findings to elucidate dynamics during HBV replication.
Skills the Lab Values
cryo-electron microscopycell cultureprotein purificationmolecular modelinggenomic analysis
Output against the department
Publications87bottom 21% of dept.224th of 286
this lab
most publishedleast published
Citations2.7kbottom 20% of dept.230th of 286
this lab
most citedleast cited
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