University of California-San Diego · PharmacologyGutkind Lab
Jorge Silvio Gutkind · La Jolla, California
Research Focus
Dr. Jorge Silvio Gutkind's lab at UC San Diego focuses on improving treatments for head and neck cancer, a disease that currently has low survival rates and limited responses to conventional therapies. The lab is investigating how disruptions in certain cellular signaling pathways contribute to cancer progression and immune evasion. They are also exploring innovative approaches using chemokines to enhance the effectiveness of immunotherapies, aiming to make treatments more successful for patients.
head and neck cancerimmune checkpoint blockadeHippo-YAP signalingchemokinestumor microenvironmentcancer immunotherapysingle-cell transcriptomicssyngeneic mouse modelstumor progression
Research Aims
5AIM 01Investigate the role of Hippo-YAP/TEAD signaling in head and neck cancer development.
AIM 02Explore the impact of chemokines on the tumor immune microenvironment to improve immunotherapy responses.
AIM 03Develop novel combinations of targeted treatments and immunotherapy for HNSCC patients.
AIM 04Understand the mechanisms of immune evasion in head and neck cancer.
AIM 05Profile immune cell populations in the tumor microenvironment.
Skills the Lab Values
cell culturegenetically engineered mouse modelsimmunohistochemistryRNA sequencingflow cytometryWestern blotspatial transcriptomicsanimal handlingdata analysis with Rexperimental design
Output against the department
Publications1,286top 2% of dept.7th of 462
this lab
most publishedleast published
Citations67ktop 3% of dept.13th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.