Case Western Reserve University · GeneticsColorectal Cancer Genetics Lab
Zhenghe Wang · Cleveland, Ohio
Research Focus
Dr. Zhenghe Wang's lab focuses on understanding the role of a specific gene known as PTPRT in the development and spread of colorectal cancer. They investigate how mutations in this gene disrupt normal cellular processes, resulting in cancer cell growth and metastasis. The lab aims to discover new therapeutic targets by exploring the mechanisms behind protein modifications that influence cancer progression.
colon cancerPTPRTmetastasisprotein tyrosine nitrationsignaling pathways
Research Aims
3AIM 01Investigate the role of PTPRT denitrase in regulating paxillin signaling in colorectal cancer.
AIM 02Explore the effects of PTPRT denitrase on ERK nitration and its implications for cancer progression.
AIM 03Establish the importance of protein tyrosine nitration in tumor development and metastasis.
Skills the Lab Values
molecular cloningcell culturemouse modelsgenetic engineeringWestern blottingimmunohistochemistrybioinformaticssignal transduction analysis
Output against the department
Publications154bottom 49% of dept.131st of 259
this lab
most publishedleast published
Citations9.7kbottom 49% of dept.132nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.