Cleveland State University · GeneticsRamamoorthy Erythropoiesis Lab
Mahesh Ramamoorthy · Cleveland, Ohio
Research Focus
Dr. Mahesh Ramamoorthy's lab at Cleveland State University focuses on understanding how specific proteins influence blood cell development, especially in the production of hemoglobin. They study a protein called Stag1, which plays a crucial role in the maturation of red blood cells. By uncovering the mechanisms of how Stag1 regulates gene expression during this process, the lab aims to provide insights that could lead to new treatments for blood disorders like anemia and thalassemia.
cohesinerythropoiesishemoglobin synthesisgene regulationblood disorders
Research Aims
3AIM 01Determine the role of Stag1 in regulating transcription during erythropoiesis.
AIM 02Explore the effects of Stag1 depletion on globin gene expression.
AIM 03Investigate how Stag1 influences promoter-enhancer interactions during red blood cell development.
Skills the Lab Values
molecular cloningCRISPR/Cas technologychromatin immunoprecipitationRNA sequencingcell culturegene expression analysisflow cytometryWestern blottingchromosome conformation capture
Output against the department
Publications34bottom 6% of dept.244th of 259
this lab
most publishedleast published
Citations1.2kbottom 5% of dept.246th of 259
this lab
most citedleast cited
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