Brown University · BiologyThe OncoViral Lab
Sean Edward Lawler · Providence, Rhode Island
Research Focus
Dr. Sean Edward Lawler's lab at Brown University focuses on understanding how cytomegalovirus (CMV) influences glioblastoma, a type of aggressive brain cancer. By using a special mouse model where the virus is present, the lab aims to uncover the interactions between CMV and tumor growth, which could lead to new treatments for patients. The research highlights the potential of CMV as a therapeutic target and seeks to improve therapy effectiveness in glioblastoma patients.
CytomegalovirusGlioblastomaCancer therapyTumor microenvironmentImmunotherapyChemo-resistancePericytesPDGFDViral replication
Research Aims
3AIM 01Investigate PDGFD as a therapeutic target in glioblastoma.
AIM 02Explore mechanisms by which CMV enhances tumor progression.
AIM 03Examine the effects of CMV on tumor and immune interactions during therapy.
Skills the Lab Values
Mouse modelsCRISPRCell cultureImmunohistochemistryRNA sequencingTumor xenograftsBiostatisticsFlow cytometrySurvival analysis
Output against the department
Publications413top 11% of dept.116th of 1,033
this lab
most publishedleast published
Citations14ktop 26% of dept.270th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.