University of California-San Diego · PharmacologyDaneman Neurovascular Lab
Richard Daneman · La Jolla, California
Research Focus
Dr. Richard Daneman's lab investigates how blood vessels in the brain function, specifically in the context of Alzheimer's disease. They focus on a protein called SOX18, which appears to play a crucial role in maintaining the health of these blood vessels and preventing problems that may contribute to Alzheimer's. By studying both mouse models and human cell systems, the lab aims to understand the mechanisms behind blood vessel dysfunction in Alzheimer's and explore potential therapies targeting SOX18.
Alzheimer's diseaseneurovascular dysfunctionSOX18blood-brain barrierproteomics
Research Aims
3AIM 01Examine how Sox18 affects blood vessel function in the brain.
AIM 02Identify molecular mechanisms by which Sox18 regulates neurovascular health.
AIM 03Test whether changing Sox18 levels can alter Alzheimer's disease progression.
Skills the Lab Values
mouse modelscell cultureCRISPRproteomicsin vitro assays
Output against the department
Publications136bottom 39% of dept.284th of 462
this lab
most publishedleast published
Citations23ktop 14% of dept.65th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.