Johns Hopkins University · NeuroscienceBlackshaw Neurogenesis Lab
Seth Blackshaw · Baltimore, Maryland
Research Focus
Dr. Seth Blackshaw's lab at Johns Hopkins University focuses on understanding how retinal progenitor cells develop and differentiate into various cell types in the retina. Through their research, they explore the genetic networks that control these processes and aim to find new ways to reprogram glial cells to generate neurons that are crucial for vision. Their work has important implications for developing therapies for vision restoration in diseases like macular degeneration and glaucoma.
retinal developmentgene regulatory networksneurogenesistemporal patterningcell-based therapiesretinal progenitor cellsglial cellsvision restorationmacular degenerationglaucoma
Research Aims
5AIM 01Identify gene regulatory networks controlling temporal changes in retinal progenitor cells.
AIM 02Determine how transcription factors affect cell composition and gene expression during retinal development.
AIM 03Investigate the role of transcription factors in regulating neurogenesis and proliferation.
AIM 04Reprogram Müller glia into early-stage retinal progenitor cells using transcription factors.
AIM 05Develop techniques for improving the differentiation of retinal cells for therapeutic applications.
Skills the Lab Values
single-cell RNA sequencingATAC-seqcell culturegene expression analysisin vivo studiesgain of function assaysloss of function assayselectroporationchromatin conformation profilingtranscription factor analysis
Output against the department
Publications386top 16% of dept.108th of 671
this lab
most publishedleast published
Citations21ktop 21% of dept.139th of 671
this lab
most citedleast cited
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