University of Pittsburgh-Pittsburgh Campus · Biomedical EngineeringLaymon Neurobiology Lab
Charles Laymon · Pittsburgh, Pennsylvania
Research Focus
Dr. Charles Laymon's lab at the University of Pittsburgh focuses on understanding how the aging brain clears waste, particularly beta-amyloid, which is linked to Alzheimer's disease. The lab investigates the role of various physiological systems, such as the efflux pump at the blood-brain barrier and cerebrospinal fluid dynamics, in maintaining brain health. Their research aims to identify early changes that could indicate Alzheimer's risk, ultimately seeking therapeutic targets to prevent the disease.
Alzheimer's Diseasebeta-amyloidblood-brain barriercerebrospinal fluidP-glycoproteinneuroimagingaging brainefflux pumpbrain fluid dynamicstherapeutic targets
Research Aims
5AIM 01Examine the role of P-glycoprotein in Alzheimer's disease-related beta-amyloid clearance.
AIM 02Investigate cerebrospinal fluid dynamics in the aging brain.
AIM 03Identify neuroimaging markers that predict future beta-amyloid deposition.
AIM 04Characterize early physiological changes linked to Alzheimer's disease.
AIM 05Explore potential therapeutic targets for preventing Alzheimer's-related cognitive decline.
Skills the Lab Values
PET imagingMRI techniquesdata analysislongitudinal studiesbiomechanicscerebrospinal fluid assessmentneuroimaging marker evaluationstatistical modelingbiological sample collectionresearch methodology
Output against the department
Publications244top 42% of dept.243rd of 595
this lab
most publishedleast published
Citations3.0kbottom 22% of dept.465th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.