Vanderbilt University · BiochemistrySanders Lab
Charles R Sanders · Nashville, Tennessee
Research Focus
Dr. Charles R. Sanders’ lab at Vanderbilt University studies Charcot-Marie-Tooth Disease (CMT), a genetic disorder that affects the nerves and causes muscle weakness. The lab is particularly interested in understanding how mutations in a specific protein called PMP22 lead to the disease. By investigating how PMP22 is processed within cells, the lab aims to uncover the mechanisms behind this condition and seek potential therapeutic targets.
Charcot-Marie-Tooth DiseasePMP22peripheral nervous systemprotein traffickingSchwann cells
Research Aims
3AIM 01Investigate how the trafficking of wild type PMP22 differs from misfolded mutant forms involved in CMT.
AIM 02Examine the role of the BAG6 complex in the cytosolic trafficking of PMP22.
AIM 03Determine if excess wild type PMP22 affects proteasome function and induces stress responses in Schwann cells.
Skills the Lab Values
cell culturefluorescence microscopyprotein purificationmolecular cloningWestern blotautophagy assaysgenetic manipulationbiochemical assaysanalytical techniques for protein analysis
Output against the department
Publications313top 20% of dept.80th of 402
this lab
most publishedleast published
Citations11ktop 46% of dept.183rd of 402
this lab
most citedleast cited
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