Columbia University in the City of New York · BiologyBreast Cancer Dynamics Lab
Kevin L. Gardner · New York, New York
Research Focus
Dr. Kevin L. Gardner's lab focuses on understanding breast cancer, particularly in women of African ancestry and those in the African diaspora, who face higher mortality rates from this disease. The lab investigates a protein called Kaiso, exploring its potential as a biomarker for predicting breast cancer outcomes and how it interacts with the tumor microenvironment. By combining advanced genetic analysis techniques, the research aims to develop better prognostic models and therapeutic strategies for breast cancer.
breast cancerbiomarkersKaisotumor microenvironmentAfrican ancestrymulti-omicsgene expressionextracellular vesiclesimmune evasionprognostic models
Research Aims
5AIM 01Validate Kaiso as a predictive biomarker for breast cancer survival in diverse populations.
AIM 02Integrate multi-omic data to understand the relationships between genetic ancestry and breast cancer outcomes.
AIM 03Investigate how Kaiso influences extracellular vesicle secretion and tumor behavior.
AIM 04Characterize the immune microenvironment of breast cancers with varying Kaiso expression.
AIM 05Develop prognostic models based on clinicopathological features and tumor biology.
Skills the Lab Values
tumor microenvironment analysisquantitative multiplex immunofluorescenceRNA sequencingwhole-exome sequencingmouse xenograft modelscell culture techniquesmultiplex immunohistochemistrybioinformaticsdata analysis in clinical researchmolecular biology techniques
Output against the department
Publications251top 24% of dept.247th of 1,033
this lab
most publishedleast published
Citations5.0kbottom 38% of dept.644th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.