UWMUniversity of Wisconsin-Madison · Biology
Evans Lab
David T Evans · Madison, Wisconsin
Research Focus
David T Evans' lab at the University of Wisconsin-Madison focuses on understanding how natural killer (NK) cells recognize and respond to viral infections, particularly simian immunodeficiency virus (SIV), a model for HIV. The research explores the interactions between NK cell receptors and their ligands, aiming to uncover the mechanisms that enable NK cells to distinguish between infected and healthy cells. The findings may contribute significantly to the development of NK cell-based therapies for viral infections.
Natural Killer CellsSIVHIVImmunogeneticsKIR ReceptorsMHC Class IPeptide BindingAdaptive Immune ResponseAnimal ModelsInfection Mechanisms
Research Aims
3AIM 01Determine how KIR polymorphisms influence NK cell receptor interactions.
AIM 02Investigate the role of viral peptides in NK cell differentiation of infected cells.
AIM 03Assess the impact of adaptive NKG2C+ NK cells on SIV infection outcomes.
Skills the Lab Values
NK Cell IsolationFlow CytometryAntibody CloningAnimal HandlingImmunological AssaysMHC Tetramer TechnologyCell CultureData AnalysisImmunohistochemistryViral Peptide Synthesis
Output against the department
Publications147top 46% of dept.479th of 1,033
this lab
most publishedleast published
Citations9.3ktop 41% of dept.422nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.