Indiana University-Purdue University-Indianapolis · BiologyMoutinho Neuroprotection Lab
Miguel Moutinho · Indianapolis, Indiana
Research Focus
Dr. Miguel Moutinho's lab at Indiana University Indianapolis focuses on developing innovative therapies for Alzheimer's Disease and tauopathies using existing FDA-approved drugs. By activating a specific receptor in the brain, they aim to enhance neuroprotection and mitigate the pathological effects associated with these neurodegenerative diseases. Their research utilizes various mouse models to evaluate the effectiveness of these treatments and understand the underlying biological mechanisms.
Alzheimer's DiseaseHCAR2neuroinflammationtau pathologymicrogliaFDA-approved drugstherapeuticsneuroprotectionmouse models
Research Aims
5AIM 01Evaluate the therapeutic efficacy of FDA-approved drugs on Alzheimer's Disease models.
AIM 02Analyze the transcriptomic profiles of microglia treated with HCAR2 agonists.
AIM 03Study the impact of HCAR2 activation on tau pathology in preclinical models.
AIM 04Investigate the cellular mechanisms of HCAR2 action on neurodegeneration.
AIM 05Determine the pharmacokinetic profiles of HCAR2 agonists in mouse models.
Skills the Lab Values
RNA sequencingdrug administration techniquesmouse modelsmicroglial culturebehavioral assessmentsWestern blotimmunohistochemistrytranscriptomic analysisanimal handling
Output against the department
Publications56bottom 14% of dept.888th of 1,033
this lab
most publishedleast published
Citations1.9kbottom 13% of dept.901st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.