Rowan University · BiologyLaboratory of Asymmetric Organ Development
Natalia Shylo · Glassboro, New Jersey
Research Focus
Dr. Natalia Shylo's lab focuses on understanding how our internal organs develop asymmetrically, even when our bodies appear symmetrical on the outside. The research primarily involves studying veiled chameleons to uncover the evolutionary mechanisms behind left-right patterning of organs, which is crucial for proper organ placement and has significant implications for understanding congenital heart malformations. By examining cellular behaviors and genetic pathways involved in these processes, the lab aims to advance knowledge in developmental biology and evolutionary medicine.
left-right patterningevolutionary developmental biologycellular mechanicsCRISPRasymmetric gene expressionveiled chameleonscalcium signalinggenome editinglive imaging
Research Aims
5AIM 01Determine the mechanics of L-R patterning in veiled chameleons.
AIM 02Evaluate genetic changes in the L-R patterning pathway across amniotes.
AIM 03Investigate cellular movements and their role in molecular symmetry.
AIM 04Establish the first scRNA-seq libraries for chameleons and other amniotes.
AIM 05Explore the evolutionary conservation of L-R patterning mechanisms.
Skills the Lab Values
CRISPR gene editingcell culture techniquesadvanced microscopylive imagingsingle-cell RNA sequencingcomputational biologysurgical techniques for embryoscalcium imagingdata analysis
Output against the department
Publications37bottom 6% of dept.969th of 1,033
this lab
most publishedleast published
Citations489bottom 2% of dept.1,014th of 1,033
this lab
most citedleast cited
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