Icahn School of Medicine at Mount Sinai · NeuroscienceShuman Neurobiology Lab
Tristan Shuman · New York, New York
Research Focus
Dr. Tristan Shuman's lab focuses on understanding brain activity related to memory and cognitive impairments in disorders like epilepsy and Alzheimer's disease. By studying how brain regions communicate and synchronize, especially during episodes of abnormal firing, the lab aims to uncover mechanisms driving cognitive deficits. The research combines advanced techniques such as optogenetics and electrophysiology to manipulate and monitor brain activity in mouse models of these neurological conditions.
temporal lobe epilepsycognitive impairmentelectrophysiologyoptogeneticsAlzheimer's diseasedentate spikesneuronal synchronizationmouse modelsinterneuron activitymemory deficits
Research Aims
4AIM 01Characterize how neural activity is synchronized across the medial entorhinal cortex and hippocampus during dentate spikes.
AIM 02Determine the impact of altered interneuron timing on seizure susceptibility and cognitive performance in epilepsy.
AIM 03Investigate how medial entorhinal cortex function changes in early Alzheimer's disease compared to normal cognition.
AIM 04Examine the breakdown of neural synchrony across regions as Alzheimer's disease progresses.
Skills the Lab Values
in vivo electrophysiologyoptogeneticssilicon probe recordingscalcium imagingmouse behavioral assayselectrical stimulationneural circuit analysisdata acquisition and analysisviral vector design
Output against the department
Publications49bottom 10% of dept.599th of 671
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.502nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.