Washington University in St Louis · BiologyCorbo Retinal Lab
Joseph Corbo · Saint Louis, Missouri
Research Focus
Joseph Corbo's lab is focused on understanding and treating retinal degeneration, particularly retinitis pigmentosa, a common cause of blindness. The lab explores innovative therapies that knock out specific genes to prevent the degeneration of photoreceptors, which are essential for vision. By utilizing advanced techniques such as CRISPR and examining multiple animal models, the lab aims to develop strategies that might help a wide range of genetic forms of blindness.
photoreceptor degenerationretinitis pigmentosagene-independent therapyCRISPRneuroprotectionmouse modelsgenetic heterogeneityretinal dystrophytranscription factorsgene knockout
Research Aims
3AIM 01Test the neuroprotective effects of Nr2e3 knockout in various models of photoreceptor degeneration.
AIM 02Evaluate the potential of AAV-delivered CRISPR-Cas9 to knock out Nr2e3 in mouse models.
AIM 03Identify downstream neuroprotective factors affected by Nr2e3 knockout using RNA-seq.
Skills the Lab Values
animal modelsCRISPR-Cas9RNA sequencingbehavioral assayscell assayselectrophysiologyimmunohistochemistrymolecular assaysgenetic engineeringdata analysis
Output against the department
Publications136bottom 49% of dept.524th of 1,033
this lab
most publishedleast published
Citations10ktop 38% of dept.388th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.