University of Florida · GeneticsGene Therapy Innovations Lab
Eric T Wang · Gainesville, Florida
Research Focus
Dr. Eric T Wang's lab focuses on improving gene therapies by leveraging alternative splicing, which is a way our genes can create different proteins. The lab works on making gene therapies safer and more effective by designing gene expressions that are specific to certain tissues in the body, reducing toxicity. With innovative approaches involving AAV (adeno-associated virus), the research aims to develop self-regulating gene therapies that can adapt to their environment, particularly for diseases affecting muscles and the nervous system.
gene therapyalternative splicingAAVtissue-specific expressionauto-regulation
Research Aims
5AIM 01Develop tissue-specific splicing patterns to control cargo expression in gene therapy.
AIM 02Optimize gene expression cassettes to avoid toxicity in non-target tissues.
AIM 03Create self-regulating gene therapies that can sense and adjust their expression levels.
AIM 04Test innovative designs in cellular models of motor neuron diseases.
AIM 05Establish guidelines for incorporating alternative splicing in future gene therapies.
Skills the Lab Values
cell culture techniquesmolecular cloningRNA sequencingbioinformaticsgene expression analysis
Output against the department
Publications156top 50% of dept.128th of 259
this lab
most publishedleast published
Citations15ktop 39% of dept.101st of 259
this lab
most citedleast cited
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