University of Texas Southwestern Medical Center · BiochemistryShahmoradian Neurotoxicity Lab
Sarah H Shahmoradian · Dallas, Texas
Research Focus
Dr. Sarah H. Shahmoradian's lab focuses on understanding how the aggregation of a protein called TDP-43 causes damage to nerve cells, particularly in the context of neurodegenerative diseases like Alzheimer's and ALS. By studying how TDP-43 alters the structures in neurons known as P-bodies, the lab aims to uncover new mechanisms of neurotoxicity and identify potential markers for age-related dementia. Through advanced imaging and sequencing techniques, the research could offer insights into treating these debilitating conditions.
TDP-43neurotoxicityP-body functionAlzheimer's diseaseALSneurodegenerationRNA metabolismfrontotemporal dementiaphase separation
Research Aims
4AIM 01Investigate how TDP-43 aggregates disrupt P-body morphology in neurons.
AIM 02Determine changes in RNA metabolism in neurons affected by TDP-43 aggregation.
AIM 03Identify potential pathological markers for dementia related to TDP-43 aggregates.
AIM 04Explore the in vivo effects of TDP-43 protein aggregation on neuron function.
Skills the Lab Values
immunohistochemistryElectron MicroscopyRNA sequencinglight microscopycell cultureprotein extractionWestern blotdata analysisgenetic sequencing
Output against the department
Publications39bottom 4% of dept.385th of 402
this lab
most publishedleast published
Citations1.9kbottom 7% of dept.375th of 402
this lab
most citedleast cited
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