Harvard University · Microbiology & ImmunologyOne-Carbon ImmunoLab
Arlene H. Sharpe · Cambridge, Massachusetts
Research Focus
Dr. Arlene H. Sharpe's lab at Harvard Medical School focuses on enhancing the body's immune response against tumors by investigating the role of one-carbon metabolism. The team studies how supplementing with certain metabolites can improve the effectiveness of cancer therapies that use immune checkpoint blockade. Their work aims to uncover the mechanisms behind these processes, ultimately leading to better treatments for cancer patients.
cancer immunotherapyone-carbon metabolismPD-1 blockademetabolomicsT cell function
Research Aims
5AIM 01Investigate the cellular mechanisms by which formate supplementation enhances CD8+ T cell function.
AIM 02Explore the metabolic pathways impacted by formate supplementation in anti-tumor immunity.
AIM 03Define transcriptional and epigenetic changes in T cells under PD-1 blockade.
AIM 04Create a spatial atlas of metabolic and functional immune responses in tumors.
AIM 05Identify new therapeutic targets for improving cancer treatment outcomes.
Skills the Lab Values
mass spectrometrycell cultureconditional knockout modelsin vivo studiesimmunofluorescencemetabolite tracingspatial metabolomicsgene expression analysisdata analysisflow cytometry
Output against the department
Publications739top 2% of dept.12th of 486
this lab
most publishedleast published
Citations111ktop 1% of dept.4th of 486
this lab
most citedleast cited
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