University of Michigan-Ann Arbor · Biomedical EngineeringOvarian Cancer Mechanotransduction Lab
Geeta Mehta · Ann Arbor, Michigan
Research Focus
Dr. Geeta Mehta's lab focuses on understanding the early stages of ovarian cancer, specifically how mutated cells from the fallopian tubes migrate and form tumors. The lab uses innovative microfluidic devices and bioreactors to mimic the fluid environment around these cells, allowing them to study how fluid shear stress affects cell behavior, replication, and potential tumor formation. Their research aims to uncover new insights that could lead to better detection methods and therapies for ovarian cancer.
ovarian cancershear stressmicrofluidicstumor biologycell migrationmechanotransductionbioreactorsfallopian tubesearly detection
Research Aims
5AIM 01Investigate the role of fluid shear stress in the migration of mutated fallopian tube cells.
AIM 02Understand how shear stress affects cell replication and tumor formation.
AIM 03Identify molecular pathways activated in fallopian tube cells under shear stress.
AIM 04Test the tumor formation ability of shear-stressed cancer cells in mice.
AIM 05Establish mechanisms for early detection of ovarian cancer through biomarker development.
Skills the Lab Values
microfluidic device fabricationbioreactor designcell culture techniquesin vivo mouse modelsmolecular pathway analysisgenetic mutation assessmentimmunotherapy testing3D cell culturefluorescence microscopy
Output against the department
Publications295top 32% of dept.187th of 595
this lab
most publishedleast published
Citations7.0ktop 48% of dept.283rd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.