University of Miami · PharmacologyKazanietz Cancer Lab
Marcelo G. Kazanietz · Coral Gables, Florida
Research Focus
Dr. Marcelo G. Kazanietz's lab at the University of Miami focuses on understanding the mechanisms behind lung and prostate cancers, particularly how certain proteins, like protein kinase C (PKC), influence cancer development and disparities in outcomes. By utilizing advanced genetic engineering and animal models, the lab investigates how PKC contributes to cancer growth, metastasis, and the differences in disease progression seen in different populations, especially in prostate cancer among African American men.
lung cancerprostate cancerPKCcancer disparitiesmetastasistumor microenvironmentRac-GEFsKRASgene expressionCRISPR
Research Aims
3AIM 01Investigate the role of protein kinase C epsilon in lung cancer initiation and progression.
AIM 02Identify the mechanisms through which PKC affects cancer cell motility and metastasis.
AIM 03Explore racial disparities in prostate cancer by studying PKC expression in tumors from different demographics.
Skills the Lab Values
CRISPRgenetically engineered mouse modelsRNA sequencinggene expression analysisimmunohistochemistrycell cultureWestern blotin vivo tumor modelsfluorescence microscopyanimal handling
Output against the department
Publications310top 26% of dept.119th of 462
this lab
most publishedleast published
Citations16ktop 23% of dept.108th of 462
this lab
most citedleast cited
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