University of Michigan-Ann Arbor · BiologyEpigenetics and Cancer Therapeutics Lab
Tomasz Cierpicki · Ann Arbor, Michigan
Research Focus
Dr. Tomasz Cierpicki's lab at the University of Michigan focuses on understanding the role of epigenetic changes in cancer, specifically breast cancer and leukemia. The laboratory investigates small molecule inhibitors that target specific proteins involved in gene regulation, aiming to develop new treatments that can inhibit cancer cell growth and promote differentiation of stem cells. Researchers will gain insights into molecular biology and drug development processes relevant for cancer therapy.
breast cancerleukemiaepigeneticssmall molecule inhibitorsNSD3PRC1cancer therapychemical probes
Research Aims
5AIM 01Develop small molecule probes that target the NSD3 SET domain to impair breast cancer progression.
AIM 02Optimize inhibitors for PRC1 to promote differentiation of leukemic cells.
AIM 03Evaluate the efficacy of chemical probes in vivo using mouse models.
AIM 04Investigate the role of histone modifications in cancer cell growth and survival.
AIM 05Characterize the binding affinity and inhibitory activity of new compounds.
Skills the Lab Values
medicinal chemistryxenograft modelspharmacokineticscell culturedrug designbiochemical assaysanimal modelssmall molecule screeningstructure-based designflow cytometry
Output against the department
Publications320top 17% of dept.172nd of 1,033
this lab
most publishedleast published
Citations7.8ktop 48% of dept.492nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.