University of Alabama at Birmingham · Microbiology & ImmunologyNiederweis Pathogenesis Lab
Michael Niederweis · Birmingham, Alabama
Research Focus
Dr. Michael Niederweis' lab investigates how the bacterium Mycobacterium tuberculosis survives within the human host. They focus on the secretion of toxins and siderophores, which help the bacteria evade the immune system and acquire essential nutrients like iron. By studying these mechanisms, the lab aims to identify potential targets for new tuberculosis treatments and improve our understanding of how this pathogen causes disease.
Mycobacterium tuberculosistoxinssiderophoresdrug resistancevirulencecell deathiron acquisitionpathogenesis
Research Aims
5AIM 01Investigate the molecular mechanisms of toxin secretion by Mycobacterium tuberculosis.
AIM 02Understand the role of siderophores in iron acquisition for Mycobacterium tuberculosis.
AIM 03Analyze the drug efflux mechanisms that contribute to resistance against tuberculosis treatments.
AIM 04Explore the impact of host cell death pathways on Mycobacterium tuberculosis survival.
AIM 05Identify potential therapeutic targets in the secretion systems of Mycobacterium tuberculosis.
Skills the Lab Values
cell culturemolecular cloningbiochemical assaysprotein purificationflow cytometrymouse modelsgenetic mutagenesisWestern blotPCR
Output against the department
Publications181top 37% of dept.179th of 486
this lab
most publishedleast published
Citations12ktop 31% of dept.151st of 486
this lab
most citedleast cited
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