Washington University in St Louis · ChemistryAmyloid Protein Research Lab
Michael L Gross · Saint Louis, Missouri
Research Focus
Dr. Michael L Gross's research group at Washington University focuses on understanding the aggregation of amyloid proteins, particularly in relation to Alzheimer's disease. By utilizing advanced techniques like mass spectrometry and protein footprinting, the lab investigates how these proteins misfold and interact with each other and lipids, honing in on potential therapeutic targets. This innovative approach aims to uncover the complexities of protein behavior in neurodegenerative conditions, contributing valuable insights to the field of neurological research.
Alzheimer's diseaseamyloid proteinsprotein aggregationmass spectrometryneurodegenerationneural reprogrammingApolipoprotein Eprotein footprinting
Research Aims
4AIM 01Investigate the aggregation pathways of amyloid beta and ApoE proteins.
AIM 02Characterize the soluble intermediates of protein aggregation using protein footprinting.
AIM 03Analyze how lipids and other small molecules affect amyloid aggregation.
AIM 04Develop improved analytical techniques for studying amyloid protein behavior in vitro.
Skills the Lab Values
mass spectrometryprotein footprintinghydrogen/deuterium exchange (HDX)free radical chemistrydata analysis using Pythonkinetic modelingcell culture techniqueslipid-protein interaction studies
Output against the department
Publications1,211top 2% of dept.5th of 216
this lab
most publishedleast published
Citations32ktop 13% of dept.28th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.