Creighton University · BiologyThe RNA Immune Response Lab
Annemarie Shibata · Omaha, Nebraska
Research Focus
Dr. Annemarie Shibata's lab at Creighton University investigates how long non-coding RNAs affect the immune responses of microglia, which are immune cells in the brain. They study these mechanisms to understand and potentially develop new therapies for neurodegenerative diseases such as multiple sclerosis. The lab combines various techniques and models to unravel the roles of these RNA molecules in inflammation and neurotoxicity.
microglialong non-coding RNAsneurodegenerative diseaseneuroinflammationmultiple sclerosisgene expression
Research Aims
5AIM 01Identify differential expression of lncRNAs in microglia from mouse models of neurodegenerative disease.
AIM 02Elucidate the biological function of lncRNAs in primary microglial cells.
AIM 03Evaluate the relationship between lncRNAs and proinflammatory gene expression in microglia.
AIM 04Investigate the regulation of neurotoxicity by microglial lncRNAs.
AIM 05Explore potential therapeutic targets for neurodegenerative diseases.
Skills the Lab Values
cell cultureRNA interferencequantitative reverse transcription PCRin vitro modelsin vivo modelschromatin remodelingimmunofluorescence microscopyexperimental designdata analysis
Output against the department
Publications46bottom 10% of dept.925th of 1,033
this lab
most publishedleast published
Citations1.5kbottom 9% of dept.939th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.