Augusta University · PhysiologyRed Blood Cell Dynamics Lab
Paul Michael O'Connor · Augusta, Georgia
Research Focus
Dr. Paul Michael O'Connor's lab focuses on understanding how red blood cell (RBC) trapping contributes to kidney injuries caused by ischemia. By investigating this mechanism, the lab aims to inform better treatment strategies for acute kidney injury (AKI), a life-threatening condition that often leads to chronic kidney problems. The research has the potential to change how we view and treat kidney injuries related to RBC dynamics and heme toxicity.
acute kidney injuryischemiared blood cellskidney functiontubular injuryheme toxicitypathogenesismicrovasculature
Research Aims
3AIM 01Investigate how RBC trapping causes tubular injury and loss of kidney function.
AIM 02Examine the effects of intravascular pressures on heme release from RBCs in the kidney.
AIM 03Explore how early interventions can mitigate kidney injury in ischemic conditions.
Skills the Lab Values
animal modelsfluorescent dyeselectron microscopyendocytosistissue samplingrenal function assessmentbiochemical assaysdata interpretationstatistical analysis
Output against the department
Publications140bottom 46% of dept.153rd of 286
this lab
most publishedleast published
Citations3.8kbottom 30% of dept.199th of 286
this lab
most citedleast cited
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