Iowa State University · NeuroscienceThe IDOL Research Hub
Jie Gao · Ames, Iowa
Research Focus
Dr. Jie Gao's lab at Ohio State University focuses on understanding Alzheimer's disease and the regulatory mechanisms of a protein called IDOL, which affects the functioning of key receptors in the brain. By exploring how IDOL influences the metabolism of lipoproteins like ApoE and their role in brain health, the lab aims to uncover new therapeutic strategies for combating Alzheimer's. This research is essential in the search for effective treatments for this debilitating condition.
Alzheimer's DiseaseApolipoprotein EIDOLmicroglial functionneurodegenerationpathologycognitive functionsynaptic transmissionmetabolic reprogramming
Research Aims
3AIM 01Define the role of IDOL in microglial response to amyloid pathology.
AIM 02Elucidate mechanisms by which IDOL-LDLR axis facilitates microglial metabolism.
AIM 03Investigate the role of neuronal IDOL in ApoER2 signaling and synaptic protection.
Skills the Lab Values
Genetic manipulationMouse modelsRNA sequencingWestern blotCell cultureMicroscopyFlow cytometryImmunohistochemistryPhagocytosis assays