University of Rochester · GeneticsHHV6A and Alzheimer's Research Lab
Margot Mayer-Proschel · Rochester, New York
Research Focus
Dr. Margot Mayer-Proschel's lab at the University of Rochester focuses on understanding the role of the Human Herpesvirus 6A (HHV6A) in Alzheimer's disease. The research investigates how a specific gene from the virus, U94A, affects brain cells and may contribute to the development of Alzheimer's by impairing neuronal function and exacerbating pathology. Through cellular models and mouse studies, the lab aims to uncover the mechanisms by which HHV6A infection can influence cognitive deficits and overall disease progression.
Alzheimer's diseaseHHV6Aviral latencyneuronal cell functionglycoproteins
Research Aims
3AIM 01Investigate how U94A expression affects amyloid accumulation in neural cells from familial Alzheimer's disease patients.
AIM 02Assess the impact of U94A on cellular pathologies in mouse models of familial Alzheimer's disease.
AIM 03Evaluate whether U94A-induced cellular impairments can lead to cognitive deficits in Alzheimer's mouse models.
Skills the Lab Values
cell culturegene expression analysisanimal modelsimmunohistochemistryRNA sequencing
Output against the department
Publications61bottom 14% of dept.221st of 259
this lab
most publishedleast published
Citations4.8kbottom 26% of dept.192nd of 259
this lab
most citedleast cited
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