University of Texas Southwestern Medical Center · NeuroscienceEssential Tremor Biomarker Lab
Elan D Louis · Dallas, Texas
Research Focus
Dr. Elan D. Louis's lab focuses on exploring essential tremor (ET), a common neurological condition that affects millions of Americans. The lab is investigating the use of PET imaging to measure a potential biomarker, synaptic vesicle glycoprotein 2A (SV2A), which may help diagnose ET and track its progression, a crucial development given the lack of current biomarkers for this disease. Their research not only aims to enhance diagnostic accuracy but also aims to differentiate ET from related movement disorders.
essential tremorbiomarkerssynaptic densityPET imagingneurologymovement disordersneurodegenerationSV2Acerebellum
Research Aims
3AIM 01Measure synaptic density in essential tremor patients using SV2A PET imaging and compare it to matched controls.
AIM 02Assess the validity of SV2A PET binding as a diagnostic tool for essential tremor and its distinction from other movement disorders.
AIM 03Validate PET imaging data by examining SV2A levels in post-mortem brain samples from essential tremor patients.
Skills the Lab Values
PET imagingautoradiographyclinical correlational studiesstatistical analysisbrain tissue analysisdata interpretationneurological assessmentbiomarker validationexperiment design
Output against the department
Publications836top 5% of dept.35th of 671
this lab
most publishedleast published
Citations29ktop 13% of dept.89th of 671
this lab
most citedleast cited
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