University of Texas Southwestern Medical Center · BiologyThe OncoModel Lab
Diego H Castrillon · Dallas, Texas
Research Focus
Dr. Diego H. Castrillon's lab focuses on understanding the molecular mechanisms behind endometrial cancer and developing advanced mouse models for studying intestinal cancer. By investigating the role of the PAX2 gene in endometrial carcinogenesis and creating new models that reflect the genetic complexities of human tumors, the lab aims to improve early detection and treatment strategies for these prevalent cancers.
endometrial cancerintestine cancerPAX2tumor modelsmutation rates
Research Aims
5AIM 01Investigate the mechanisms of PAX2 loss in endometrial cancer.
AIM 02Understand PAX2's role as a tumor suppressor in the endometrium.
AIM 03Develop mouse models that reflect the mutational burden of human intestinal cancers.
AIM 04Study the impact of inflammation on intestinal cancer progression.
AIM 05Improve strategies for early detection and treatment of endometrial and intestinal cancers.
Skills the Lab Values
mouse modelscancer cell line cultureRNA sequencingChIP-seqpathology analysis
Output against the department
Publications169top 39% of dept.406th of 1,033
this lab
most publishedleast published
Citations19ktop 21% of dept.214th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.