California Institute of Technology · ChemistryShan Lab
Shu-Ou Shan · Pasadena, California
Research Focus
Dr. Shu-Ou Shan's lab at Caltech focuses on understanding how proteins are made and folded correctly inside cells, which is essential for maintaining a healthy balance of proteins in our bodies. The research investigates specific processes like how proteins get chemical modifications while being formed and how helper proteins exist to guide these processes. By studying these intricate mechanisms, the lab aims to uncover why certain diseases occur when protein production goes wrong.
protein biogenesiscotranslational mechanismsprotein foldingribosomechaperonesmitochondrial biogenesisprotein quality controlacetylationN-terminal modifications
Research Aims
3AIM 01Investigate how nascent proteins acquire chemical modifications during translation.
AIM 02Understand the role of cotranslational chaperones in protein folding.
AIM 03Explore mitochondrial protein biogenesis and quality control mechanisms.
Skills the Lab Values
protein purificationribosome profilingcell cultureco-immunoprecipitationflow cytometryWestern blottingmicroscopyN-acetyltransferase assaysgenetic manipulation
Output against the department
Publications156bottom 37% of dept.135th of 216
this lab
most publishedleast published
Citations6.6kbottom 41% of dept.128th of 216
this lab
most citedleast cited
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