Johns Hopkins University · NeurosciencePaul Lab
Bindu Paul · Baltimore, Maryland
Research Focus
Dr. Bindu Paul's lab at Johns Hopkins University is studying how hydrogen sulfide, a gas produced in the brain, protects against neurodegeneration, particularly in Alzheimer's disease. The team aims to uncover the specific molecules and pathways that are affected by hydrogen sulfide, which could lead to new therapies for age-related brain diseases. Their research combines molecular biology techniques with behavioral studies in mouse models to explore these protective mechanisms.
hydrogen sulfideAlzheimer's diseasecysteine metabolismneuroprotectiongasotransmitterssulfhydrationbehavioral studiesmouse modelsneurodegenerationbiomarkers
Research Aims
5AIM 01Elucidate the signaling pathways modulated by hydrogen sulfide in the brain.
AIM 02Monitor expression and activity of hydrogen sulfide biosynthetic enzymes across different ages.
AIM 03Assess the involvement of hydrogen sulfide in stress responses and behavior in mice.
AIM 04Identify differentially sulfhydrated proteins in Alzheimer's disease mouse models.
AIM 05Understand the regulation of hydrogen sulfide signaling related to neuroprotection.
Skills the Lab Values
molecular biology techniquesmouse modelsWestern blotimmunohistochemistryRNA sequencingcell culturedata analysisbehavioral assaysprotein purificationsignal transduction assays
Output against the department
Publications160top 46% of dept.306th of 671
this lab
most publishedleast published
Citations10ktop 40% of dept.266th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.