Washington University in St Louis · BiochemistryBurgers Replication Lab
Peter M Burgers · Saint Louis, Missouri
Research Focus
Dr. Peter M. Burgers' lab focuses on understanding how DNA replication works in cells and what happens when this process goes wrong. They use yeast as a model organism to investigate the mechanisms behind DNA replication, the consequences of errors in this process, and how cells respond to such errors. The aim is to uncover the intricate details of these pathways which are essential for maintaining genetic integrity and preventing diseases like cancer.
DNA replicationDNA damageyeast modelcheckpoint responsemutagenesis
Research Aims
5AIM 01Study the mechanisms of DNA replication in eukaryotic cells.
AIM 02Investigate the effects of replication errors on mutagenesis.
AIM 03Explore the activation of cell cycle checkpoints in response to DNA damage.
AIM 04Unravel the dual regulatory function of Rev1 in DNA lesion bypass and mutagenesis.
AIM 05Understand the activation of protein kinases Mec1 and Tel1 during DNA replication stress.
Skills the Lab Values
PCRbiochemical assaysgenetic manipulationcryoelectron microscopycell culturebiophysical analysisyeast geneticsprotein purificationWestern blot
Output against the department
Publications232top 33% of dept.132nd of 402
this lab
most publishedleast published
Citations20ktop 21% of dept.86th of 402
this lab
most citedleast cited
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