University of Virginia-Main Campus · PhysiologyKenworthy Membrane Lab
Anne K Kenworthy · Charlottesville, Virginia
Research Focus
Anne K. Kenworthy's lab focuses on understanding caveolins, unique proteins that influence how cells function by shaping their membranes. The research investigates how these proteins contribute to cellular processes like metabolism and cardiovascular health, especially in contexts where they malfunction. By employing advanced techniques like cryo-electron microscopy, the lab aims to unravel the mysteries of caveolin structure and function, which may provide insights into various diseases such as cancer and muscular dystrophy.
caveolinsmembrane proteinscardiovascular physiologycell biologystructural biology
Research Aims
5AIM 01Determine the structural features of caveolin-2 and its role in caveolae formation.
AIM 02Investigate how caveolins interact with themselves and other proteins to maintain membrane integrity.
AIM 03Explore the mechanisms by which caveolin complexes influence membrane morphology.
AIM 04Understand the impact of mutations on the function of non-conventional caveolins.
AIM 05Examine the relationship between caveolins and various physiological processes in health and disease.
Skills the Lab Values
cryo-electron microscopycell culturebiochemical assaysbiophysical analysiscomputational modeling
Output against the department
Publications170top 42% of dept.120th of 286
this lab
most publishedleast published
Citations16ktop 18% of dept.52nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.