Washington University in St Louis · Biomedical EngineeringThe Estrogen Insight Lab
Kooresh Isaac Shoghi · Saint Louis, Missouri
Research Focus
Dr. Kooresh Isaac Shoghi's lab focuses on improving treatment options for patients with advanced breast cancer by studying how certain therapies work with estrogen receptors. Specifically, they investigate the use of PET imaging to predict which patients might benefit from hormone therapies instead of more aggressive treatments like chemotherapy. This research aims to make cancer treatment more personalized and effective for patients with hormone-sensitive breast cancer.
breast cancerendocrine therapypredictive biomarkersestrogen receptorPET imagingprecision medicinehormone therapytumor genomicspatient-derived xenografts
Research Aims
3AIM 01Evaluate the impact of ESR1 gene mutations on estrogen receptor function and imaging biomarkers.
AIM 02Assess the predictive utility of FFNP-PET in various endocrine therapy contexts.
AIM 03Investigate the relationship between tumor genomics and response to therapy in clinical trials.
Skills the Lab Values
PET imagingtumor xenograft modelsgenetically engineered mouse modelsgene expression analysisclinical trial designbiopsy techniquesdata analysis in cancer researchmolecular biology techniquesgenomic sequencing
Output against the department
Publications237top 44% of dept.257th of 595
this lab
most publishedleast published
Citations5.2kbottom 40% of dept.358th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.