Oregon Health & Science University · BiochemistryThayer Lab
Mathew J Thayer · Portland, Oregon
Research Focus
Dr. Mathew J. Thayer's lab focuses on understanding the molecular and cellular mechanisms that underlie Down syndrome and its link to early-onset Alzheimer's disease. By investigating the role of epigenetic regulation at critical genes on chromosome 21, the lab aims to elucidate how variations in gene expression may contribute to the symptoms associated with these conditions. This research not only advances our understanding of these diseases but also holds potential for developing new therapeutic strategies.
Down SyndromeAlzheimer's Diseaseepigeneticsgene expressionchromosome 21
Research Aims
5AIM 01Investigate the epigenetic mechanisms involved in allelic inactivation of dosage sensitive genes.
AIM 02Examine the connection between Down syndrome and early-onset Alzheimer's disease.
AIM 03Develop cell-based assays to study gene expression patterns in human and mouse models.
AIM 04Elucidate the role of Inactivation/Stability Centers on chromosome 21.
AIM 05Challenge existing models of autosomal random monoallelic expression.
Skills the Lab Values
cell culturemouse modelsPCRRNA sequencingWestern blot
Output against the department
Publications86bottom 19% of dept.325th of 402
this lab
most publishedleast published
Citations4.8kbottom 28% of dept.291st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.